Jekyll-Hyde neurotrophins: the story of proNGF.

Psychologising Jekyll, Demonising Hyde: The Strange Case of Criminal Responsibility

This paper puts the famous story of Jekyll and Hyde to work for a specific analytic purpose. The question of responsibility for crime, complicated by the divided subjectivity implicit in Mr. Hyde’s appearance, and illuminated by Robert Louis Stevenson’s grasp of contemporary psychiatric, evolutionary, and medical thought as promising new technologies for effecting a distinction between criminal...

Dr. Jekyll or Mr. Hyde: Information Security in the Ecosystem of Healthcare

“Jekyll and Hyde” embodies how information security affects today’s healthcare ecosystem. When security works, it promotes patient health and a smooth operating ecosystem (Dr. Jekyll); when it doesn’t, privacy and health compromises can occur (Mr. Hyde). In this paper, we argue that unusable security triggers this split personality and in doing so, compromises the heart of the healthcare ecosys...

An Optimized Procedure for the Site-Directed Labeling of NGF and proNGF for Imaging Purposes

Neurotrophins are growth factors of fundamental importance for the development, survival and maintenance of different neuronal and non-neuronal populations. Over the years, the use of labeled neurotrophins has helped in the study of their biological functions, leading to a better understanding of the processes that regulate their transport, traffic, and signaling. However, the diverse and heter...

Dynamic Structure of NGF and proNGF Complexed with p75NTR: Pro-Peptide Effect

Crystallographic structures of NGF/p75NTR and proNGF/p75NTR were previously obtained in 2:1 and 2:2 stoichiometries, respectively. However, evidence shows that both stoichiometries can occur for mature neurotrophins and pro-neurotrophins. We used Molecular Dynamics (MD) simulations to examine the energetic and structural characteristics of these two complete systems as well as the uncomplexed f...

Two Honeysuckles: A Tale of Dr. Jekyll and Mr. Hyde